Set a 6-quart oval slow cooker to low. Line the insert with a large sheet of parchment paper, making sure it extends up the sides. Lightly coat the parchment with nonstick cooking spray.
Add the graham crackers to a food processor and pulse until fine crumbs form.
Add the melted butter and pulse again until evenly combined.
Transfer the mixture to the slow cooker and press firmly and evenly into the bottom to form the crust.
In a stand mixer, beat the cream cheese and granulated sugar until smooth and creamy, scraping down the sides as needed.
Add the sour cream, eggs, flour, vanilla extract, and salt. Beat just until fully combined and smooth—do not over mix.
Pour the cheesecake filling over the crust and smooth the top.
Cover with the lid and cook on low for 5–7 hours, or until a skewer inserted into the center comes out clean. Periodically wipe condensation from the lid to prevent moisture from dripping onto the cheesecake.
Remove the slow cooker insert and refrigerate for at least 3 hours, or until fully set.
Lift the cheesecake out using the parchment paper, peel it away, slice, and serve.